Scientific programme

Preliminary Programme

Monday, 17 June

12.00-13.00Registration, outside room X, floor 2
13.00-13.15Welcome address, room X, floor 2 (Gunnar Pejler)
13.15.14.55 Session I: Mast cell biology: basics and future
(chaired by Lars Hellman and Silvia Bulfone Paus)
13.15-13.55 K Frank Austen (Harvard Medical School): “Intrinsic and extrinsic directed diversity of tissue mast cells”
13.55-14.15 Magda Babina (Charité - Universitätsmedizin Berlin): “MRGPRX2 and human skin mast cells - functional aspects and regulation by extracellular cues”
14.15-14.25 Petr Draber (Academy of Sciences of the Czech Republic): “ORMDL3 regulates leukotriene biosynthesis and chemotaxis in mast cells”
14.25-14.35 Karla Alina Ramirez-Valadez (Unidad Coapa, México): “Participation of Fyn kinase in the migration of mast cells in response to transforming growth factor β”
14.35-14.45 Gokhan Cildir (University of South Australia): “Immunoglobulin E (IgE)-mediated mast cell activation governs a novel chromatin landscape”
14.45-14.55 Edismauro Garcia Freitas Filho (University of São Paulo): “RACK1: a new scaffold hub for regulated secretion in mast cells”
14.55-15.35Coffee break, poster mounting
15.35-17.45Session II: Mast cells/basophils, IgE and inflammatory lung disease
(chaired by Sara Wernersson and Frank Redegeld)
15.35-16.15 Stephen J Galli (Stanford University): "Mast cells and IgE in health and disease"
16.15-16.35 Jenny Hallgren Martinsson (Uppsala University): “The significance of mast cell progenitors in allergic asthma”
16.35-16.55 Jonas Erjefält (Lund University): ”Disease and Microenvironments as Determinants for Tissue Mast cell Phenotypes”
16.55-17.05 Kwok Ho Yip (Centre for Cancer Biology, Adelaide): “A novel role of cytokine receptor common beta subunit in amplifying FcεRI-mediated mast cell activation”
17.05-17.15 Anna-Karin Johnsson (Karolinska Institutet): “Characterization of lipid mediator release in IgE stimulated human CBMC’s and lung mast cells”
17.15-17.25 Jane Warner (University of Southampton): “Combining immunofluorescent imaging and micro-CT to visualize mast cells and 3D networks in human lung tissue”
17.25-17.35 Aida Paivandy (Uppsala University): “Mechanism of oxidative stress-induced mast cell apoptosis in response to granule permeabilization”
17.35-17.45 Lars Hellman (Uppsala University): “Highly selective cleavage of TH2 promoting cytokines by human mast cell tryptase and chymase”
17.45-20.00Poster session I (snacks and drinks)

P1 - 2B4 direct interactions with Staphylococcus aureus exotoxins play an important role in allergy and bacterial infection
P2 - A novel Kit D816V mutated cell model for mastocytosis
P3 - Activated mast cells contribute to chronic inflammatory conditions in sickle cell anemia
P4 - Amelioration of MRGPRX2-mediated itch and reduced mast cell degranulation by a singlestranded oligonucleotide
P5 - Anti-allergic effects of Inotodiol from Chaga mushroom via a selective mast cell-stabilizing activity
P6 - Ataxin-3, a SCA3 neurodegenerative disorder protein, affects mast cell functions
P7 - Can mast cell progenitors be activated by IgE crosslinking?
P8 - Capitalizing on paradoxical activation of the MAPK pathway for treatment of imatinib-resistant mast cell leukemia
P9 - Characterization of Histaminergic Angioedema and Chronic Spontaneous Urticaria with Angioedema
P10 - Characterization of Rab12 Interactions with its Rab-Interacting Lysosomal Protein (RILP) Family Effectors
P11 - CholU patients exhibit higher numbers of mast cells in the skin
P12 - Different use of BTK and PLC in FceRI- and KIT-activated mast cells: a minor role of BTK upon KIT activation
P13 - Effects Of PI3K Inhibitors On Human Lung And Cord Blood-Derived Mast Cells
P14 - Ex vivo human skin microdialysis as a tool to investigate allergic reactions and mast cell responses in the skin
P15 - FXII-inhibiting effects reduce due to cleavage of Mast cell chymase to C1 inhibitor.
P16 - Glutamate triggers the expression of ionotropic and metabotropic glutamate receptors in mast cells
P17 - Human Basophils Express Vanilloid Receptor 1 and are Responsive to Stimulation with Capsaicin and Lysophosphatidic Acid
P18 - Human Mast Cells Produce The Mammalian Chondroitin Hydrolase, Hyaluronidase 4
P19 - Hyper-proliferation in mast cells: does tryptase have a role?
P20 - IL-1beta activates IL-3 primed human basophils with a higher potency than IL-33
P21 - Immune response against HtrA proteases as a potential marker in mast cell- related diseases in children
P22 - Interleukin (IL)-33: novel inducer of mast cell proliferation and new therapeutic target for allergic diseases
P23 - Interleukin-33: a double-edged sword in mast cell responses to rhinovirus infection
P24 - Intraepithelial Mast Cells in Asthmatic Patients are Associated with Less Symptoms and Improved Wound Healing Responses
P25 - Investigating red meat allergy in an alpha Gal deficient mouse model
P26 - Lung Cancer-Derived Microvesicles: a mediator of mast cell activation in the tumor microenvironment
P27 - Mas-related-G-protein-coupled-receptor X2 mediated degranulation of HMC1 cells cultured with latrunculin B

Tuesday, 18 June

08.00-09-00 EMBRN board meeting, seminar room 3 (“seminarierum 3”), floor 2, congress venue
09.00-10.30 Session III: Basophil biology
(chaired by Stephan Bischoff and Carole Oskeritzian)
09.00-09.30 Hajime Karasuyama (Tokyo Medical and Dental University): “Crucial role for basophils in emphysema development in a murine model of COPD”
09.30-09.50 Merav Cohen (Weizmann Institute of Science): “Single cell interaction map reveals a novel role for basophils in lung development”
09.50-10.10 Joakim Dahlin (Karolinska Institute): “Dissection of the basophil-mast cell fate decision at the single-cell level”
10.10-10.20 Yasmine Lamri (Université Paris Diderot): “Basophils contribute to Mixed Connective Tissue Disease (Sharp syndrome) development”
10.20-10.30 Christophe Pellefigues (Malaghan Institute of Medical Research): “Basophils induce the skin barrier dysfunction and participate in the resolution of atopic dermatitis”
10.30-11.00Coffee break
11.00-11.40Session III, continued
11.00-11.20 Nicholas Charles (Université Paris Diderot): “Basophils and IgE in systemic autoimmune diseases”
11.20-11.30 Bernhard F. Gibbs (University of Oldenburg): “Human Basophils are Recruited in Bullous Pemphigoid and are Activated by IgE-Dependent Mechanisms”
11.30-11.40 Sylvia M.T. Groen (University of Oldenburg): “Serotonin Inhibits IgE-Dependent IL-4 Secretion from Human Basophils”
11.40-13.00Session IV: A mast cell/basophil smorgasbord
(chaired by Ronit Sagi-Eisenberg and Peter Bradding)
11.40-12.00 Anne Dudeck (Otto-von-Guericke University Magdeburg): “Mast cell and Dendritic cell communication and mutual arming to ensure acute host defense" 12.00-12.20 Hans-Jürgen Hoffmann (Aarhus University & Hospital): “Basophil activation as a model for the allergic response”
12.20-12.30 Edouard Leveque (Cancer Research Center of Toulouse): “Eicosanoids: a new step in deciphering mast cells/ CD4+ T cells Crosstalk”
12.30-12.40 Zou Xiang (Guizhou Medical University, China): “Fc  receptor-dependent mast cell apoptosis regulates tissue persistence”
12.40-12.50 Yiyu Wang (Charité – Universitätsmedizin Berlin): “Lyn controls Syk-independent FceRI signaling in Mast Cells”
12.50-13.00 Christopher Von Beek (Uppsala University): “Streptococcal streptolysin S encoded by sagA activates a pro-inflammatory response in mast cells by a sublytic mechanism”
13.00-14.00Lunch (served at congress venue)
14.00-16.00Session V: Mast cells and basophils in disease
(chaired by Magnus Åbrink and Francesca Levi-Schaffer)
14.00-14.20 Silvia Monticelli (Università della Svizzera Italiana): “Transcriptional and posttranscriptional regulation of mast cells”
14.20-14.40 Gunnar Nilsson (Karolinska Institute): “Single-cell analysis to reveal mast cell development in mastocytosis”
14.40-15.00 Adrian Piliponsky (Seattle Children's Research Institute): “Basophil-derived tumor necrosis factor can enhance innate immunity in a sepsis model in mice”
15.00-15.10 Qingqing Jiao (Universitätsmeidzin Berlin): “Skin mast cells contribute to Sporothrix schenckii infection”
15.10-15.20 Flavie Ngo Nyekel (Paris Diderot University): “Mast cell degranulation exacerbates skin rejection by enhancing neutrophil recruitment”
15.20-15.30 Yana Arestova (Charité – Universitätsmedizin Berlin): “Mast cells modulate antigenspecific CD8 T cell activation during viral infections”
15.30-15.40 Roberta Sulsenti (Istituto Nazionale dei Tumori, Milan): “Mast cells- derived osteopontin protects from neuroendocrine prostate cancer”
15.40-15.50 Martin Houde (Université de Sherbrooke): “Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction”
15.50-16.00 Rajia Bahri (University of Manchester): “The melanoma micro-milieu alters mast cell characteristics and conditions their activities”
16.00-18.00Poster session II (drinks + snacks)

P28 - Mast cell activation and microtubule organization is modulated by miltefosine through protein kinase C inhibition
P29 - Mast cell exosomes stimulate collagen synthesis
P30 - Mast cell extracellular trap formation upon bacterial stimulation occurs independently of reactive oxygen species
P31 - Mast cell protease activity in sputum of asthma patients during and out of pollen season
P32 - Mast cell proteases regulate inflammation and impairs anti-viral response in human bronchial epithelial cells
P33 - NvCI carboxypeptidase inhibitor dampens airway hyperreactivity and goblet cell hyperplasia in a model of allergic asthma
P34 - PI3K-dependent regulation of FOXO1 tunes the inflammatory response of mast cells
P35 - Polyphenols affect circadian expression of clock genes and chemokines in human mast cells
P36 - Protective role of mouse mast cell tryptase mMCP6 in melanoma
P37 - Protein Tyrosine Phosphatase SHP-1 Regulates Microtubule Nucleation in Mouse Bone Marrow-Derived Mast Cells
P38 - Proteomic profiling of lipid rafts isolated from RBL-2H3 mast cells
P39 - RBL-MRGPRX2 cells are a valid model for dissecting the underlying mechanisms of MRGPRX2 function
P40 - Resveratrol and nobiletin inhibit IgE-antigen–mediated STAT3 activation in mast cells
P41 - Role of mast cells in melanoma brain metastases: Identification of primary cancer-specific prognostic mediators.
P42 - Selectivity of the human mast cell tryptase for positively charged substrates
P43 - Syk and Nf-kB are critical for basophil activation by diverse stimuli
P44 - The Basoph8xiDTR mice allow a reliable identification and a specific conditional depletion of basophils.
P45 - The frequency of circulating mast cell progenitors correlates with female gender and reduced lung function
P46 - The function and regulation of IL-33 and ATP in mast cell activation
P47 - The mast cell chymase locus during 400 million years of tetrapod evolution
P48 - The mouse chymase MCP-4 regulates intestinal inflammatory responses during infection with Giardia intestinalis
P49 - The MRGPRX2 agonist Cortisatin-14 degranulates human skin mast cells in vitro and in vivo
P50 - The role of complement anaphylatoxins C3a and C5a in human mast cell function
P52 - The Role Of Myosin1f In Ige-Dependent And Independent Degranulation In Mast Cells.
P53 - Valproic acid modulates FcERI mediated mast cell activation
P54 - Wnt signaling activates human mast cells and cause cytokine release
P55 - Skin microbiome regulates stem cell factor (SCF) level in Keratinocytes and defines mast cell maturation
P56 - Microbiota-mast cell interactions in a humanized mouse model of IBS
P57 - Novel method for assessing basophil activation by measuring altered expression of membranebound and intracellular basogranulin stores
19.00Conference dinner (Norrlands Nation)

Wednesday, 19 June

09.00-09.50EMBRN general assembly (all EMBRN members welcome)
09.50-10.20Coffee break
10.20-12.00Session VI: Mast cell and basophils: therapy and diagnostics
(chaired by Bernard Gibbs and Bettina Jensen)
10.20-10.40 Ana Olivera (NIH): ”Mastocytosis-derived extracellular vesicles with a mast cell signature as unsuspected contributors to disease pathology”
10.40-10.50 Jelle Folkerts (Utrecht University): “Butyrate Inhibits Human Mast Cell Activation Through Regulation of Expression of Key Signal Transducers”
10.50-11.00 Jesper Säfholm (Karolinska Institutet): “Prostacyclin Inhibits Mannitol-induced Contractions of Isolated Human Small Airways”
11.00-11.10 Carole A. Oskeritzian (University of South Carolina): “Newly uncovered angiogenic remodeling in asymptomatic eczema requires mast cells and sphingosine kinase 1”
11.10-11.20 Susanne Kaesler (University Munich): “Targeting melanoma-resident mast cells to boost tumor immune defense”
11.20-11.30 Devavani Chatterjea (Macalester College): “Tetrahydrocannabinol reduces DNFBdriven vaginal mast cell accumulation and persistent genital pain in ND4 outbred mice”
11.30-12.00 Marcus Maurer (Charité - Universitätsmedizin Berlin): “Mast cells and basophils as therapeutic targets – past, present, future”
12.00-12.10 Presentation of EMBRN 2021
12.10-12.30 Prize ceremony (travel grants; attendance required for eligibility)
12.30-12.40 Closing remarks: Gunnar Pejler

Get the programme as a PDF for EMBRN 2019 (will open in a separate window)